"Scandals" - Animals Evolved from Cancer Cells

Panchin knows the idea of cancer-derived animals sounds far-fetched — so much so that, in the paper, he and his co-authors refer to them as Scandals (an acronym for “speciated by cancer development animals”). [...] According to Panchin’s three-step scenario, a Scandal would start off as a cancer, but not just any cancer. It would have to be transmissible, so that it wouldn’t die when its host did. Then the cancer would have to spread to other species, and then independently evolve multicell...

 The Fundamentals of Cancer

Cancer, we now know, is a disease caused by the uncontrolled growth of a single cell. This growth is unleashed by mutations—changes in DNA that specifically affect genes that incite unlimited cell growth. In a normal cell, powerful genetic circuits regulate cell division and cell death. In a cancer cell, these circuits have been broken, unleashing a cell that cannot stop growing. That this seemingly simple mechanism—cell growth without barriers—can lie at the heart of this grotesque and mult...

 DNA Divergence is in How You Count

It’s a common misconception that chimp DNA differs from Homo sapiens sapiens genes by only a single percent, but this number is apocryphal. In actuality, the degree of similarity of human and chimp genetic code depends mostly on how you count. Since all complex organisms from Earth possess great swaths of junk DNA inherited from a distant common ancestor, there tends to be startling similarity between many organisms. Sure, humans are like chimps—but they’re also like flatworms and fruit flies...

 Nogo receptor 1 Key to a Plastic Mind

Formation of lasting memories is believed to rely on structural alterations at the synaptic level. We had found that increased neuronal activity down-regulates Nogo receptor-1 (NgR1) in brain regions linked to memory formation and storage, and postulated this to be required for formation of lasting memories. We now show that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both...